Could try below to see if anything out of the ordinary:
pi@ph5b:~ $ sudo -u pihole pihole-FTL debug
[2022-07-13 19:51:42.311 15229M] Using log file /var/log/pihole/FTL.log
[2022-07-13 19:51:42.314 15229M] ########## FTL started on ph5b! ##########
[2022-07-13 19:51:42.317 15229M] FTL branch: master
[2022-07-13 19:51:42.319 15229M] FTL version: v5.16.1
[2022-07-13 19:51:42.321 15229M] FTL commit: 5ff5bed
[2022-07-13 19:51:42.323 15229M] FTL date: 2022-07-08 08:44:12 +0100
[2022-07-13 19:51:42.324 15229M] FTL user: pihole
[2022-07-13 19:51:42.325 15229M] Compiled for armv6hf (compiled on CI) using arm-linux-gnueabihf-gcc (crosstool-NG crosstool-ng-1.22.0-88-g8460611) 4.9.3
[2022-07-13 19:51:42.328 15229M] Creating mutex
[2022-07-13 19:51:42.330 15229M] Creating mutex
[2022-07-13 19:51:42.339 15229M] Starting config file parsing (/etc/pihole/pihole-FTL.conf)
[2022-07-13 19:51:42.342 15229M] SOCKET_LISTENING: only local
[2022-07-13 19:51:42.345 15229M] AAAA_QUERY_ANALYSIS: Show AAAA queries
[2022-07-13 19:51:42.347 15229M] MAXDBDAYS: max age for stored queries is 365 days
[2022-07-13 19:51:42.349 15229M] RESOLVE_IPV6: Resolve IPv6 addresses
[2022-07-13 19:51:42.351 15229M] RESOLVE_IPV4: Resolve IPv4 addresses
[2022-07-13 19:51:42.353 15229M] DBINTERVAL: saving to DB file every minute
[2022-07-13 19:51:42.355 15229M] DBFILE: Using /etc/pihole/pihole-FTL.db
[2022-07-13 19:51:42.357 15229M] MAXLOGAGE: Importing up to 24.0 hours of log data
[2022-07-13 19:51:42.359 15229M] PRIVACYLEVEL: Set to 0
[2022-07-13 19:51:42.361 15229M] IGNORE_LOCALHOST: Show queries from localhost
[2022-07-13 19:51:42.362 15229M] BLOCKINGMODE: Null IPs for blocked domains
[2022-07-13 19:51:42.363 15229M] ANALYZE_ONLY_A_AND_AAAA: Disabled. Analyzing all queries
[2022-07-13 19:51:42.366 15229M] DBIMPORT: Importing history from database
[2022-07-13 19:51:42.366 15229M] PIDFILE: Using /run/pihole-FTL.pid
[2022-07-13 19:51:42.368 15229M] PORTFILE: Using /run/pihole-FTL.port
[2022-07-13 19:51:42.370 15229M] WARNING: Unable to write used port to file
[2022-07-13 19:51:42.372 15229M] (API might not find the port)
[2022-07-13 19:51:42.374 15229M] SOCKETFILE: Using /run/pihole/FTL.sock
[2022-07-13 19:51:42.376 15229M] SETUPVARSFILE: Using /etc/pihole/setupVars.conf
[2022-07-13 19:51:42.377 15229M] MACVENDORDB: Using /etc/pihole/macvendor.db
[2022-07-13 19:51:42.379 15229M] GRAVITYDB: Using /etc/pihole/gravity.db
[2022-07-13 19:51:42.381 15229M] PARSE_ARP_CACHE: Active
[2022-07-13 19:51:42.383 15229M] CNAME_DEEP_INSPECT: Active
[2022-07-13 19:51:42.385 15229M] DELAY_STARTUP: No delay requested.
[2022-07-13 19:51:42.386 15229M] BLOCK_ESNI: Enabled, blocking _esni.{blocked domain}
[2022-07-13 19:51:42.389 15229M] NICE: Set process niceness to -10 (default)
[2022-07-13 19:51:42.390 15229M] MAXNETAGE: Removing IP addresses and host names from network table after 365 days
[2022-07-13 19:51:42.392 15229M] NAMES_FROM_NETDB: Enabled, trying to get names from network database
[2022-07-13 19:51:42.393 15229M] EDNS0_ECS: Overwrite client from ECS information
[2022-07-13 19:51:42.394 15229M] REFRESH_HOSTNAMES: Periodically refreshing IPv4 names
[2022-07-13 19:51:42.397 15229M] RATE_LIMIT: Rate-limiting client making more than 1000 queries in 60 seconds
[2022-07-13 19:51:42.398 15229M] LOCAL_IPV4: Automatic interface-dependent detection of address
[2022-07-13 19:51:42.401 15229M] LOCAL_IPV6: Automatic interface-dependent detection of address
[2022-07-13 19:51:42.402 15229M] BLOCK_IPV4: Automatic interface-dependent detection of address
[2022-07-13 19:51:42.405 15229M] BLOCK_IPV6: Automatic interface-dependent detection of address
[2022-07-13 19:51:42.405 15229M] SHOW_DNSSEC: Enabled, showing automatically generated DNSSEC queries
[2022-07-13 19:51:42.407 15229M] MOZILLA_CANARY: Enabled
[2022-07-13 19:51:42.409 15229M] PIHOLE_PTR: internal PTR generation enabled (pi.hole)
[2022-07-13 19:51:42.411 15229M] ADDR2LINE: Enabled
[2022-07-13 19:51:42.413 15229M] REPLY_WHEN_BUSY: Drop queries when the database is busy
[2022-07-13 19:51:42.415 15229M] BLOCK_TTL: 2 seconds
[2022-07-13 19:51:42.417 15229M] BLOCK_ICLOUD_PR: Enabled
[2022-07-13 19:51:42.418 15229M] CHECK_LOAD: Enabled
[2022-07-13 19:51:42.420 15229M] CHECK_SHMEM: Warning if shared-memory usage exceeds 90%
[2022-07-13 19:51:42.422 15229M] CHECK_DISK: Warning if certain disk usage exceeds 90%
[2022-07-13 19:51:42.424 15229M] Finished config file parsing
[2022-07-13 19:51:42.435 15229M] Database version is 12
[2022-07-13 19:51:42.438 15229M] Resizing "FTL-strings" from 40960 to (81920 * 1) == 81920 (/dev/shm: 1.2MB used, 225.3MB total, FTL uses 1.2MB)
[2022-07-13 19:51:42.442 15229M] Imported 0 alias-clients
[2022-07-13 19:51:42.446 15229M] Database successfully initialized
[2022-07-13 19:51:42.490 15229M] New upstream server: 127.0.0.1:5335 (0/1024)
[2022-07-13 19:51:42.504 15229M] New upstream server: 10.0.0.2:53 (1/1024)
[2022-07-13 19:51:43.027 15229M] Resizing "FTL-queries" from 180224 to (8192 * 44) == 360448 (/dev/shm: 1.3MB used, 225.3MB total, FTL uses 1.3MB)
[2022-07-13 19:51:43.045 15229M] Imported 4230 queries from the long-term database
[2022-07-13 19:51:43.049 15229M] -> Total DNS queries: 4230
[2022-07-13 19:51:43.051 15229M] -> Cached DNS queries: 2657
[2022-07-13 19:51:43.054 15229M] -> Forwarded DNS queries: 1103
[2022-07-13 19:51:43.056 15229M] -> Blocked DNS queries: 318
[2022-07-13 19:51:43.058 15229M] -> Unknown DNS queries: 0
[2022-07-13 19:51:43.059 15229M] -> Unique domains: 254
[2022-07-13 19:51:43.060 15229M] -> Unique clients: 4
[2022-07-13 19:51:43.062 15229M] -> Known forward destinations: 2
[2022-07-13 19:51:43.064 15229M] Successfully accessed setupVars.conf
[2022-07-13 19:51:43.072 15229M] listening on 0.0.0.0 port 53
[2022-07-13 19:51:43.076 15229M] listening on :: port 53
[2022-07-13 19:51:43.083 15229M] WARNING: Unable to write PID to file.
[2022-07-13 19:51:43.086 15229M] Continuing anyway...
[2022-07-13 19:51:43.089 15229M] PID of FTL process: 15229
[2022-07-13 19:51:43.093 15229M] INFO: FTL is running as user pihole (UID 999)
dnsmasq: [2022-07-13 19:51:43.095 15229/T15232] Listening on Unix socket
started, version pi-hole-2.87test8 cachesize 10000
dnsmasq: [2022-07-13 19:51:43.097 15229/T15231] Listening on port 4711 for incoming IPv6 telnet connections
[2022-07-13 19:51:43.097 15229/T15230] Listening on port 4711 for incoming IPv4 telnet connections
DNS service limited to local subnets
dnsmasq: compile time options: IPv6 GNU-getopt no-DBus no-UBus no-i18n IDN DHCP DHCPv6 Lua TFTP no-conntrack ipset no-nftset auth cryptohash DNSSEC loop-detect inotify dumpfile
dnsmasq: using nameserver 127.0.0.1#5335
dnsmasq: using nameserver 10.0.0.2#53 for domain 0.0.10.in-addr.arpa
dnsmasq: using nameserver 10.0.0.2#53 for domain home.dehakkelaar.nl
dnsmasq: using only locally-known addresses for onion
dnsmasq: using only locally-known addresses for bind
dnsmasq: using only locally-known addresses for invalid
dnsmasq: using only locally-known addresses for localhost
dnsmasq: using only locally-known addresses for test
[2022-07-13 19:51:43.124 15229M] Reloading DNS cache
dnsmasq: read /etc/hosts - 5 addresses
dnsmasq: read /etc/pihole/custom.list - 6 addresses
dnsmasq: read /etc/pihole/local.list - 0 addresses
[2022-07-13 19:51:43.318 15229/T15233] Compiled 0 whitelist and 2 blacklist regex filters for 4 clients in 106.7 msec
[2022-07-13 19:51:43.322 15229/T15233] Blocking status is enabled
Can stop by pressing CTRLc and start here up normal again with below:
pihole restartdns