Finally, I Fixed this issue
By disabling Auto Dns Option
Stop Network Manager from adding DNS Servers Dynamically
nano /etc/NetworkManager/NetworkManager.conf
[main]
dns=none
- restart the Network Manager
systemctl restart NetworkManager.service
- Update the Pi-hole DNS Server on
/etc/resolv.conf
nano /etc/resolv.conf
nameserver <Pi-hole DNS>
nameserver 1.1.1.1
systemctl restart NetworkManager.service
Now it's Blocking the Ad's
Wireguard + Pi-hole working well