What is NXDOMAIN reply means

Hi, i'm totally newb here.
i want to know what is NXDOMAIN in reply means ?
the query is usually randomchar.lan, wpad.lan, etc. (as my pi-hole hostname is "lan")
i'm googling about wpad and found this article Disable WPAD now or have your accounts and private data compromised | Network World

so i think those wpad.lan query is not safe ?
should i block it with regex lan$ and will it work ?

It's "non-existing domain".
www.dnsknowledge.com/whatis/nxdomain-non-existent-domain-2/

It means the DNS server you asked, doesn't know the domain.

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