Unexpected entries in /etc/resolv.conf

/etc/resolv.conf on my Beta5 system has the following entries:

# Dynamic resolv.conf(5) file for glibc resolver(3) generated by resolvconf(8)
#     DO NOT EDIT THIS FILE BY HAND -- YOUR CHANGES WILL BE OVERWRITTEN
nameserver 208.67.220.220
nameserver 208.67.222.222
nameserver 2620:119:35::35
search localdomain

My v4.3.2 system has these entries:

# Dynamic resolv.conf(5) file for glibc resolver(3) generated by resolvconf(8)
#     DO NOT EDIT THIS FILE BY HAND -- YOUR CHANGES WILL BE OVERWRITTEN
nameserver 127.0.0.1
search localdomain

I never touched /etc/resolv.conf.

The beta5 system was setup on top of an (etcher) image from my v4.3.2 system, using the instructions from the original announcement. Since than, I regularly ran pihole -up and got a few pihole-FTL updates, these updates always cause an unattended setup.
I haven't changed anything outside pihole -up, I stayed on the beta5 branch, no tests of alternate branches have been done on this system.

Could this be a setup problem?
Do I remove these entries by simply editing the file, OR is there a specific command?

Beta5 is correct. We no longer force the Pi-hole device to use itself for DNS. /etc/resolv.conf is now fully under the user control.

Yes. Edit the file.

Doesn't work, after a reboot the entries are back.

Found this document, now using:

sudo mv /etc/resolv.conf /etc/resolv.conf.disabled
file=/etc/resolv.conf
echo nameserver 127.0.0.1 | sudo tee $file
echo search localdomain | sudo tee $file
sudo chown root:root $file
sudo chmod 777 $file

This survives a reboot.

Actually, don't edit /etc/resolv.conf directly as the bold header text notes. You'll have to edit the resolvconf package files, do not modify the file with chown or chattr.

/etc/resolvconf/resolv.conf.d/ and /etc/resolvconf.conf are the proper places to modify. See Debian -- File list of package resolvconf/buster/all

my name servers in Buster are set in /etc/dhcpcd.conf, as are static IP entries. This is where you will probably find those entries... (for Raspbian)