i use Cloudflare (DNSSEC) on IPv4 (no IPv6 enabled) with DNSSEC enabled.
now, whilst it is said that these are just warnings and not errors, it seems strange that they should only just start appearing after months of having none.
Packet sizes vary normally. Now you have hit a larger size than the upstream DNS server will accept. It's nothing to worry about, as long as your queries are being answered.