Pi-hole stopped working over night

Hi all,

Yesterday I set up my Pi-hole for the first time. After some initial problems with getting things to work, I thought I had arrived at a configuration that works. Ads were being filtered and DoH seemed to work. But once I woke up this morning, none of my devices could connect to the internet. It became quickly clear that something must be wrong with the Pi-hole and indeed, after rebooting everything seems to work fine.
I am a bit puzzled by this experience and would like to know what went wrong. The results of pihole -d can be found here.

Note that I have seen this post, but since there is no solution at the end, I thought it might be best to open a new topic.

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