It is manual configured (IPv4)
pi@Pi-hole:~ $ nmcli -t -f name con show --active | xargs -d '\n' -n 1 nmcli -p -f ipv4.method,ipv4.dns,ipv6.method,ipv6.dns connection show
===============================================================================
Connection profile details (eth0)
===============================================================================
ipv4.method: manual
-------------------------------------------------------------------------------
ipv4.dns: --
-------------------------------------------------------------------------------
ipv6.method: auto
-------------------------------------------------------------------------------
ipv6.dns: --
-------------------------------------------------------------------------------
===============================================================================
Connection profile details (wg0)
===============================================================================
ipv4.method: manual
-------------------------------------------------------------------------------
ipv4.dns: --
-------------------------------------------------------------------------------
ipv6.method: disabled
-------------------------------------------------------------------------------
ipv6.dns: --
-------------------------------------------------------------------------------
pi@Pi-hole:~ $
I added pi-holes address as DNS-server and set IPV6 to disabled:
pi@Pi-hole:~ $ nmcli -t -f name con show --active | xargs -d '\n' -n 1 nmcli -p -f ipv4.method,ipv4.dns,ipv6.method,ipv6.dns connection show
===============================================================================
Connection profile details (eth0)
===============================================================================
ipv4.method: manual
-------------------------------------------------------------------------------
ipv4.dns: 192.168.1.111
-------------------------------------------------------------------------------
ipv6.method: disabled
-------------------------------------------------------------------------------
ipv6.dns: --
-------------------------------------------------------------------------------
===============================================================================
Connection profile details (wg0)
===============================================================================
ipv4.method: manual
-------------------------------------------------------------------------------
ipv4.dns: --
-------------------------------------------------------------------------------
ipv6.method: disabled
-------------------------------------------------------------------------------
ipv6.dns: --
-------------------------------------------------------------------------------
pi@Pi-hole:~ $
pi@Pi-hole:~ $ sudo nft list ruleset
table ip filter {
chain INPUT {
type filter hook input priority filter; policy accept;
iifname "eth0" meta l4proto udp udp dport 51820 counter packets 4223 bytes 1131768 accept
iifname "wg0" meta l4proto udp udp dport 53 counter packets 66 bytes 4847 accept
}
chain FORWARD {
type filter hook forward priority filter; policy accept;
}
chain OUTPUT {
type filter hook output priority filter; policy accept;
}
}
table ip nat {
chain PREROUTING {
type nat hook prerouting priority dstnat; policy accept;
}
chain INPUT {
type nat hook input priority 100; policy accept;
}
chain OUTPUT {
type nat hook output priority -100; policy accept;
}
chain POSTROUTING {
type nat hook postrouting priority srcnat; policy accept;
oifname "eth0" ip saddr 10.210.160.0/24 counter packets 79 bytes 10948 masquerade
}
}
pi@Pi-hole:~ $
pi@Pi-hole:~ $ nslookup -class=chaos -type=txt version.bind 192.168.1.111
Server: 192.168.1.111
Address: 192.168.1.111#53
Non-authoritative answer:
*** Can't find version.bind: No answer
Authoritative answers can be found from:
pi@Pi-hole:~ $
pi@Pi-hole:~ $ nslookup pi.hole 192.168.1.111
Server: 192.168.1.111
Address: 192.168.1.111#53
Name: pi.hole
Address: 192.168.1.111
pi@Pi-hole:~ $
user@MacBookAir ~ % nslookup -class=chaos -type=txt version.bind 192.168.1.111
Server: 192.168.1.111
Address: 192.168.1.111#53
Non-authoritative answer:
*** Can't find version.bind: No answer
Authoritative answers can be found from:
user@MacBookAir ~ %
user@MacBookAir ~ % nslookup pi.hole 192.168.1.111
Server: 192.168.1.111
Address: 192.168.1.111#53
Name: pi.hole
Address: 192.168.1.111
user@MacBookAir ~ %
I do see at the moment when I hit enter after the command on my MacBookAir via VPN nslookup -class=chaos -type=txt version.bind 192.168.1.111 the following: Jan 7 07:54:52: gravity blocked version.bind is NODATA
and after the command nslookup pi.hole 192.168.1.111
Jan 7 07:55:46: query[A] pi.hole from 10.210.160.4
Jan 7 07:55:46: Pi-hole hostname pi.hole is 192.168.1.111
And from/on the Pi-Hole itself:
nslookup pi.hole 192.168.1.111
Jan 7 07:57:55: query[A] pi.hole from 192.168.1.111
Jan 7 07:57:55: Pi-hole hostname pi.hole is 192.168.1.111
Jan 7 07:57:55: query[AAAA] pi.hole from 192.168.1.111
Jan 7 07:57:55: Pi-hole hostname pi.hole is NODATA
nslookup -class=chaos -type=txt version.bind 192.168.1.111
Jan 7 07:59:21: query[TXT] version.bind from 192.168.1.111
Jan 7 07:59:21: gravity blocked version.bind is NODATA
So yes, that seems to work?
pihole -d works again 
Your debug token is: https://tricorder.pi-hole.net/oUQKGEs3/