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Using MacOS, Chrome Browser and trying to configure ad-blocking on Youtube but it is not working.
It is not blocking the regular ads, in the video windows and not even out of the video window.
See Screenshot bellow.
I see you are new to this forum. A search for this topic will show that YouTube ads are not easily blocked by Pi-hole, since the ads are served from the same domains as the content. Pi-hole blocks at the domain level.