That means something upstream is blocking/filtering traffic with IP 185.89.218.12:
pi@ph5b:~ $ dig +norecurse @185.89.218.12 a z-p42-instagram.c10r.facebook.com.
[..]
;; AUTHORITY SECTION:
c10r.facebook.com. 3600 IN NS a.ns.c10r.facebook.com.
c10r.facebook.com. 3600 IN NS c.ns.c10r.facebook.com.
c10r.facebook.com. 3600 IN NS b.ns.c10r.facebook.com.
c10r.facebook.com. 3600 IN NS d.ns.c10r.facebook.com.
;; ADDITIONAL SECTION:
a.ns.c10r.facebook.com. 3600 IN AAAA 2a03:2880:f0fc:b:face:b00c:0:99
a.ns.c10r.facebook.com. 3600 IN A 129.134.30.11
c.ns.c10r.facebook.com. 3600 IN AAAA 2a03:2880:f1fc:b:face:b00c:0:99
c.ns.c10r.facebook.com. 3600 IN A 185.89.218.11
b.ns.c10r.facebook.com. 3600 IN AAAA 2a03:2880:f0fd:b:face:b00c:0:99
b.ns.c10r.facebook.com. 3600 IN A 129.134.31.11
d.ns.c10r.facebook.com. 3600 IN AAAA 2a03:2880:f1fd:b:face:b00c:0:99
d.ns.c10r.facebook.com. 3600 IN A 185.89.219.11
Not related to unbound or Pi-hole.
Someone else experienced similar:
EDIT: Or maybe routes upstream are wrong somehow.
EDIT2: Below did the trick seeing something wrong with the repeated attempts and no answer:
grep 'sending query\|sending to target\|response was\|reply from\|operate: query' unbound.log | less