Since the FTL update to 6.0.2, the web interface has stopped working (see https://discourse.pi-hole.net/t/v6-web-interface-cant-be-loaded/76532/1, where I tried a completely fresh install with the same web interface problem.
So without the web interface, if I need to make this change in pihole.toml, is that a matter of changing dnsmasq_lines = [] to dnsmasq_lines = [no-0x20-encode].