Clients are connected to Pi-Hole, but blocking isn't visible

Expected Behaviour:

Clients are connected to Pi-Hole and blocking is successful.

Actual Behaviour:

Clients are connected to Pi-Hole and and Pi-Hole shows that Querys get blocked, but there's is no visible blocking of ads whatsoever. I've got about 200.000 domains on my blocklists, use a DNS upstream server which also filters malware itself (which it didn't) and all of my devices have Pi-Hole as their DNS server.

Debug Token:

https://tricorder.pi-hole.net/8flihnslyu

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