Your RegEx are unassociated again.
*** [ DIAGNOSING ]: Domainlist (0/1 = exact white-/blacklist, 2/3 = regex white-/blacklist)
id type enabled group_ids domain date_added date_modified comment
----- ---- ------- ------------ ---------------------------------------------------------------------------------------------------- ------------------- ------------------- --------------------------------------------------
1 3 1 (\.|^)reddit\.com$ 2022-07-08 22:00:08 2022-07-14 12:59:06
4 3 1 (\.|^)imgur\.com$ 2022-07-09 10:19:58 2022-07-14 12:59:06
5 3 1 (\.|^)facebook\.com$ 2022-07-09 10:20:07 2022-07-14 12:59:07
I saw that they have been recently modified. Did you perhaps turn them on/off from the Blacklist menu?
You might be affected by: Domains edited from Black/Whitelist page lose Group assignment · Issue #2260 · pi-hole/AdminLTE · GitHub
To workaround until the fix is released: use Group management/Domains instead of Black/Whitelist